Lihong Liu, PhD

  • Assistant Professor of Medical Sciences (in Medicine) at CUMC
Profile Headshot


Academic Appointments

  • Assistant Professor of Medical Sciences (in Medicine) at CUMC


  • Mandarin

Credentials & Experience

Education & Training

  • PhD, 2014 Microbiology, Institut Pasteur of Shanghai, Chinese Academy of Sciences


Selected Publications

  1. Wang Q, Iketani S, Li Z, Liu Liyuan, Guo Y, Huang Y, Bowen AD, Liu M, Wang M, Yu J, Valdez R, Lauring AS, Sheng Z, Wang HH, Gordon A, Liu L#, Ho DD#. Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants. Cell. 2023 (#corresponding author).
  2. Wang Q, Bowen A, Valdez R, Gherasim C, Gordon A#, Liu L#, Ho DD#. Antibody responses to Omicron BA.4/BA.5 bivalent mRNA vaccine booster shot. The New England Journal of Medicine. 2023 in press. (#corresponding author).
  3. Wang Q, Li Z, Ho J, Guo Y, Yeh AY, Mohri H, Liu M, Wang M, Yu J, Shah JG, Chang JY, Herbas F, Yin MT, Sobieszczyk ME, Sheng Z, Liu L#, Ho DD#. Resistance of SARS-CoV-2 omicron subvariant BA.4.6 to antibody neutralisation. Lancet Infect Dis. 2022 Oct 31:S1473-3099(22)00694-6. (#corresponding author).
  4. Wang Q, Iketani S, Li Z, Guo Y, Yeh AY, Liu M, Yu J, Sheng Z, Huang Y, Liu L#, Ho DD#. Antigenic characterization of the SARS-CoV-2 Omicron subvariant BA.2.75. Cell Host Microbe. 2022 Sep 6:S1931-3128(22)00419-X. (#corresponding author).
  5. Wang Q, Guo Y, Iketani S, Nair MS, Li Z, Mohri H, Wang M, Yu J, Bowen AD, Chang JY, Shah JG, Nguyen N, Chen Z, Meyers K, Yin MT, Sobieszczyk ME, Sheng Z, Huang Y, Liu L# & Ho DD#. Antibody evasion by SARS-CoV-2 Omicron subvariants BA. 2.12. 1, BA. 4, & BA. 5. Nature. 2022 Jul 5:1-3. (#corresponding author).
  6. Liu L, Iketani S, Guo Y, Reddem ER, Casner RG, Nair MS, Yu J, Chan JF, Wang M, Cerutti G, Li Z, Morano NC, Castagna CD, Corredor L, Chu H, Yuan S, Poon VK, Chan CC, Chen Z, Luo Y, Cunningham M, Chavez A, Yin MT, Perlin DS, Tsuji M, Yuen KY, Kwong PD, Sheng Z, Huang Y, Shapiro L & Ho DD. An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses. Science translational medicine. 2022; 14(646):eabn6859.
  7. Liu L, Meyers K, Purpura LJ, Nguyen N, Mohri H, Chang JY, Annavajhala MK, Lopez L 3rd, Lee SW, Shah J, Lane B, Cantos A, Tukuru SA, Guo Y, Ford K, Chiu YT, Sheng Z, Choesang T, Castor D, Wang M, Pili C, Van Hoy MN, Wallach A, Horton J, Chen Z, Rosenthal S, McLaren S, Jiang B, Wang F, Lu HH, Uhlemann AC, Ho DD & Yin MT. Development and performance of a point-of-care rapid antigen test for detection of SARS-COV-2 variants. Journal of clinical virology plus. 2022; 2(3):100080.
  8. Iketani S*, Liu L*, Guo Y*, Liu L*, Chan JF*, Huang Y, Wang M, Luo Y, Yu J, Chu H, Chik KK, Yuen TT, Yin MT, Sobieszczyk ME, Huang Y, Yuen KY, Wang HH, Sheng Z & Ho DD. Antibody evasion properties of SARS-CoV-2 Omicron sublineages. Nature 2022; 604(7906):553-6. (* first author).
  9. Liu L, Iketani S, Guo Y, Chan JF, Wang M, Liu L, Luo Y, Chu H, Huang Y, Nair MS, Yu J, Chik KK, Yuen TT, Yoon C, To KK, Chen H, Yin MT, Sobieszczyk ME, Huang Y, Wang HH, Sheng Z, Yuen KY & Ho DD. Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2. Nature 2022; 602(7898):676-81.
  10. Cerutti G*, Guo Y*, Liu L*, Liu L, Zhang Z, Luo Y, Huang Y, Wang HH, Ho DD, Sheng Z & Shapiro L. Cryo-EM structure of the SARS-CoV-2 Omicron spike. Cell Rep. 2022 Mar 1;38(9):110428. (* first author).
  11. Iketani S*, Liu L*, Nair MS*, Chandrashekar A, Mohri H, Wang M, Barouch DH, Huang Y, and Ho DD. Ad26.COV2.S boosts humoral and cellular immune responses following BNT162b2 vaccination. Emerging Microbes & Infections 2021; 10(1):2220-2222. (* first author).
  12. Wang P*, Nair MS*, Liu L*, Iketani S*, Luo Y, Guo Y, Wang M, Yu J, Zhang B, Kwong PD, Graham BS, Mascola JR, Chang JY, Yin MT, Sobieszczyk M, Kyratsous CA, Shapiro L, Sheng Z, Huang Y, and Ho DD. Nature 2021; Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7. Nature 2021;593, 130-135 . (* first author).
  13. Liu L*, Wang P, Nair MS, Yu J, Rapp M, Wang Q, Luo Y, Chan JF, Sahi V, Figueroa A, Guo XV, Cerutti G, Bimela J, Gorman J, Zhou T, Chen Z, Yuen KY, Kwong PD, Sodroski JG, Yin MT, Sheng Z, Huang Y, Shapiro L and Ho DD. Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike. Nature 2020; 584(7821): 450-456.
  14. Wang P*, Liu L*, Nair MS*, Yin MT*, Luo Y, Wang Q, Yuan T, Mori K, Solis AG, Yamashita M, Purpura LJ, Laracy JC, Yu J, Sodroski J, Huang Y and Ho DD. SARS-CoV-2 Neutralizing Antibody Responses Are More Robust in Patients with Severe Disease. Emerging Microbes & Infections 2020;9(1):2091-2093. (* first author).
  15. Wang Q*, Liu L*, Ren W, Gettie A, Wang H, Liang Q, Shi X, Montefiori DC, Zhou T and Zhang L. A Single Substitution in gp41 Modulates the Neutralization Profile of SHIV during In Vivo Adaptation. Cell Rep 2019; 27(9): 2593-2607 (* first author).
  16. Liu L, Wang W, Matz J, Ye C, Bracq L, Delon J, Kimata JT, Chen Z, Benichou S and Zhou P. The Glycosylphosphatidylinositol-Anchored Variable Region of Llama Heavy Chain-Only Antibody JM4 Efficiently Blocks both Cell-Free and T Cell-T Cell Transmission of Human Immunodeficiency Virus Type 1. J Virol 2016; 90(23): 10642-10659.
  17. Liu L, Wen M, Zhu Q, Kimata JT and Zhou P. Glycosyl Phosphatidylinositol-Anchored C34 Peptide Derived From Human Immunodeficiency Virus Type 1 Gp41 Is a Potent Entry Inhibitor. J Neuroimmune Pharmacol 2016; 11(3): 601-10.
  18. Liu L, Wang W, Yang L, Ren H, Kimata JT and Zhou P. Trimeric glycosylphosphatidylinositol-anchored HCDR3 of broadly neutralizing antibody PG16 is a potent HIV-1 entry inhibitor. J Virol 2013; 87(3): 1899-905.
  19. Liu L, Wen M, Wang W, Wang S, Yang L, Liu Y, Qian M, Zhang L, Shao Y, Kimata JT and Zhou P. Potent and broad anti-HIV-1 activity exhibited by a glycosyl-phosphatidylinositol- anchored peptide derived from the CDR H3 of broadly neutralizing antibody PG16. J Virol 2011; 85(17): 8467-76.