Moriya Tsuji

Profile Headshot

Overview

Academic Appointments

  • Professor of Medicine at CUMC

Languages

  • Japanese

Gender

  • Male

Credentials & Experience

Education & Training

  • MD, 1983 Medicine, The Jikei University School of Medicine
  • PhD, 1987 Immunology, University of Tokyo-Japan
  • Fellowship: 1990 New York University School of Medicine

Honors & Awards

2021 Fellow of American Society of Medicine and Hygiene (FASTMH)

04/2014 - 03/2015 Mizutani Foundation for Glycoscience Award

11/2009 - 10/2010 Gates Grand Challenges Explorations Round 3

04/1997 - 03/2002 NIH FIRST Award

09/1999 - 09/2003 NIH Independent Scientist Award

07/1996 - 06/1998 American Lung Association of New York Research Award

09/1993 - 08/1994 New York University Whitehead Presidential Award

01/1993 - 12/1993 American Cancer Society Institutional Award

04/1983 - 03/1987 Japan Scholarship Society Award

Research

Selected Publications

  • Shiratsuchi T, Rai U, Kaneko I, Zhang M, Iwanaga S, Yuda M, Tsuji M. 2017. A potent malaria vaccine based on adenovirus with dual modifications at Hexon and pVII. Vaccine. Accepted.
  • Zhang M, Mandraju R, Rai U, Shiratsuchi T, Tsuji M. 2017. Monoclonal antibodies against Plasmodium falciparum circumsporozoite protein. Antibodies 6(3), 11; doi:10.3390/antib6030011
  • Nogueira RT, Sahi V, Huang J, Tsuji M. 2017. Human IgG repertoire of malaria antigen-immunized human immune system (HIS) mice. Immunol Lett. 188: 46-52.
  • Li X, Huang J, Kawamura A, Funakoshi R, Porcelli SA, Tsuji M. 2017. Co-localization of a CD1d-binding glycolipid with an adenovirus-based malaria vaccine for a potent adjuvant effect. Vaccine. 35: 3171-3177.
  • Zhou J, Kaiser A, Ng C, Karcher R, McConnell T, Paczkowski P, Fernandez C, Zhang M, Mackay S, Tsuji M. 2017. CD8+ T-cell mediated anti-malaria protection induced by malaria vaccines; assessment of hepatic CD8+ T cells by SCBC assay. Hum Vaccin Immunother. 13: 1625-1629.
  • Steel RW, Sack BK, Tsuji M, Kappe SH. 2017. An opsonic phagocytosis assay for Plasmodium falciparum sporozoites. Clin Vaccine Immunol. 24. pii: e00445-16.
  • Li X, Huang J, Kaneko I, Zhang M, Iwanaga S, Yuda M, Tsuji M. 2017. A potent adjuvant effect of a CD1d-binding NKT cell ligand in human immune system mice. Expert Rev Vaccines 16:73-80
  • Li X, Huang J, Zhang M, Funakoshi R, Sheetij D, Spaccapelo R, Crisanti A, Nussenzweig V, Nussenzweig RS, Tsuji M. 2016. Human CD8+ T cells mediate protective immunity induced by a human malaria vaccine in human immune system mice. Vaccine 34:4501-6
  • Coelho-dos-Reis JG, Huang J, Tsao T, Pereira FV, Funakoshi R, Nakajima H, Sugiyama H, Tsuji M. 2016. Co-administration of a-GalCer analog and TLR4 agonist induces robust CD8+ T-cell responses to PyCS protein and WT-1 antigen and activates memory-like effector NKT cells. Clin Immunol. 168: 6-15.
  • Zhang M, Kaneko I, Tsao T, Mitchell R, Nardin EH, Iwanaga S, Yuda M, Tsuji M. 2016. A highly infectious Plasmodium yoelii parasites, bearing Plasmodium falciparum circumsporozoite protein. Malaria J. 15: 201.
  • Sharma A, Wu W, Sung B, Huang J, Tsao T, Li X, Gomi R, Tsuji M, Worgall S. 2016. RSV Pulmonary Infection in Humanized Mice Induces Human Anti-RSV Immune Responses and Pathology. J Virol. 90: 5068-5074. Co-corresponding author.
  • Huang J, Li X, Coelho-dos-Reis JGA, Zhang M, Mitchell R, Tayar-Nogueira R, Tsao T, Noe AR, Ayala R, Sahi V, Gutierrez GM, Nussenzweig V, Wilson JM, Nardin EH, Nussenzweig RS, Tsuji M. 2015. Human immune system mice immunized with Plasmodium falciparum circumsporozoite protein induce protective human humoral immunity against malaria. J Immunol Methods 427:42-50.
  • Li X, Kawamura A, Andrews CD, Miller JL, Wu D, Tsao T, Zhang M, Oren D, Padte NN, Porcelli SA, Wong CH, Kappe SHI, Ho DD, Tsuji M. 2015. The co-localization of a CD1d-binding glycolipid with a radiation-attemuated sporozoites vaccine in LN-resident DCs for a robust adjuvant effect. J Immunol 195: 2710-2721.
  • Huang J, Tsao T, Zhang M, Tsuji M. 2014. Circumsporozoite Protein-Specific K(d)-Restricted CD8+ T Cells Mediate Protective Antimalaria Immunity in Sporozoite-Immunized MHC-I-K(d) Transgenic Mice. Mediators Inflamm. 2014: 728939.
  • Huang J, Li X, Coelho-dos-Reis JGA, Wilson JM, Tsuji M. 2014. An AAV vector-mediated gene delivery approach facilitates reconstitution of functional human CD8+ T cells in mice. PLOS ONE 9: e88205.
  • Padte NN, Boente-Carrera M, Andrews CD, McManus J, Grasperge BF, Gettie A, Coelho-dos-Reis JGA, Li X, Levenkova N, Wu D, Bruder JT, Sedegah M, Patterson N, Richie TL, Wong CH, Ho DD, Vasan S, Tsuji M. 2013 A glycolipid adjuvant, 7DW8-5, enhances CD8+ T cell responses induced by an adenovirus-vectored malaria vaccine in non-human primates. PLOS ONE 8: e78407.
  • Coelho-dos-Reis JGA, Li X, Silveira ELV, Mandraju R, Velmurugan S, Chakravarty S, Suemizu H, Ito M, Sim BKL, Hoffman SL, Tsuji M. 2013.Plasmodium falciparum infection in “humanized liver” mice. MalariaWorld J. 4:9:1-4.
  • Kelly H, Mandraju R, Coelho-dos-Reis JGA, Tsuji M. 2013. Effects of HIV-induced CD1c and CD1d modulation and endogenous lipid presentation on CD1c-restricted T cell activation. BMC Immunol. 14: 4-14.
  • Huang J, Li X, Kohno K, Hatano M, Tokuhisa T, Murray PJ, Brocker T, Tsuji M. 2013. Generation of tissue-specific H-2Kd transgenic mice for the study of Kd-restricted malaria epitope-specific CD8+ T-cell responses in vivo. J. Immunol. Methods 387: 254-261.
  • Avci FY, Li X, Tsuji M#, Kasper DL#. 2012. Isolation of carbohydrate specific CD4+ T cell clones from two model glycoconjugate vaccines. Nat. Protoc. 7: 2180-2192 #Co-corresponding Author.
  • Li X, Polacino P, Garcia-Navarro R, Hu S-L, Tsuji M. 2012. Peripheral blood invariant natural killer T cells of pig-tailed macaques. PLoS ONE 7: e48166.
  • Rai U, Huang J, Shiratsuchi T, Li X, Mishra S, Tsuji M. 2012. A new method to determine antigen-specific CD8+ T cell activity in vivo by hydrodynamic injection. Biomolecules 2: 23-33.
  • Shiratsuchi T, Kraus A, Worgall S, Tsuji M. 2010. Replacing adenoviral vector HVR1 with a malaria B cell epitope improves immunogenicity and circumvents pre-existing immunity to adenovirus in mice. J. Clin. Inv. 120: 3688-3701.
  • Li X, Fujio M, Imamura M, Wu D,Vasan S, Wong C-H, Ho DD, Tsuji M. 2010. Design of a novel CD1d-binding NKT cell ligand as a vaccine adjuvant. Proc. Natl. Acad. Sci. USA.

Schmieg J, Yang G, Franck RW, Tsuji M. 2010. A multifactorial mechanism in the superior anti-malarial activity of a-C-GalCer. J. Biomed. Biotech.

  • Horowitz A, Li X, Poles MA, Tsuji M. 2009. Quantifying cytokine production by epitope-specific, HLA-restricted CD8+ T cells after stimulation by immobilized HLA-A2:Ig dimeric proteins. Scan. J. Immunol. 70: 415-422.
  • Li X, Shiratsuchi T, Chen G, Franck RW, Tsuji M. 2009. Invariant TCR rather than CD1d shapes the preferential activities of C-glycoside analogues against human versus murine iNKT cells. J. Immunol. 183: 4415-4421.
  • Li X, Chen G, Garcia-Navarro R, Franck RW, Tsuji M. 2009. Identification of C-glycoside analogues that display a potent activity against human NKT cells. Immunology 127: 216-225.
  • Shiratsuchi T, Schneck J, Kawamura A, Tsuji M. 2009. Human CD1 dimeric proteins as indispensable tools for research on CD1-binding lipids and CD1-restricted T cells. J. Immunol. Methods 345: 49-59.
  • Huang Y, Chen A, Li X, Chen Z, Zhang W, Song Y, Gurner D, Gardiner D, Basu S, Ho DD, Tsuji M. 2008. Enhancement of HIV DNA vaccine immunogenicity by the NKT cell ligand α-galactosylceramide. Vaccine 26: 1807-1816.
  • Vasan S, Poles MA, Horowitz A, Siladji EE, Markowitz M, Tsuji M. 2007. Percentage and function of NKT cells, a potential anti-HIV effector cell, are preserved by beginning HAART during acute and early HIV-1 Infection. Int. Immunol. 19: 943-951.
  • Ophorst OJAE, Radosevic K, Havenga MJE, Pau MG, Holterman L, Berkhout B, Goudsmit J, Tsuji M. 2006. Recombinant human adenovirus serotype 35-based malaria vaccine: Immunogenicity and protection against Plasmodium yoelii in mice. Infect. Immun. 74: 313-320.
  • Schmieg J, Yang G, Franck RW, Van Rooijen N, Tsuji M. 2005. Glycolipid-presentation to natural killer T cells differs in an organ-dependent fashion. Proc. Natl. Acad. Sci. USA. 102: 1127-1132.
  • Schmieg J, Yang G, Franck RW, Tsuji M. 2003. Superior protection against malaria and melanoma metastases by a C-glycoside analogue of the natural killer T cell ligand a-galactosylceramide. J. Exp. Med. 198: 1631-1641.
  • Bruna-Romero O, Schmieg J, Del Val M, Buschle M, Tsuji M. 2003. The dendritic cell-specific chemokine DC-CK1 enhances protective cell-mediated immunity to murine malaria. J. Immunol. 170: 3195-3203.
  • Gonzalez-Aseguinolaza G, Van Kear L, Bergmann CC, Wilson JM, Schmieg J, Kronenberg M, Nakayama T, Taniguchi M, Koezuka Y, Tsuji M. 2002. The natural killer T cell ligand α-galactosylceramide enhances protective immunity induced by malaria vaccines. J. Exp. Med. 195: 617-624.
  • Fernandez JA, Rodrigues EG, Tsuji M. 2000. Multifactorial protective mechanisms to limit viral replication in the lung of mice during primary murine cytomegalovirus infection. Viral. Immunol. 13: 287-295.
  • Gonzalez-Aseguinolaza G, de Oliveira C, Tomaska M, Hong S, Bruna-Romero O, Nakayama T, Taniguchi M, Bendelac A, Van Kaer L, Koezuka Y, Tsuji, M. 2000. α-GalCer-activated Vα14 natural killer T cells mediate protection against murine malaria. Proc. Natl. Acad. Sci. USA. 97: 8461-8466.
  • Molano A, Chiu Y-H, Nosseir S, Bendelac A, Tsuji M. 2000. Cutting Edge: The IgG response to the circumsporozoite protein is MHC class II-dependent and CD1d-independent: Exploring the role of GPIs in NKT cell activation and antimalarial responses. J. Immunol. 164: 5005-5009.
  • Rodrigues EG, Claassen J, Lee S, Wilson JM, Nussenzweig RS, Tsuji M. 2000. Interferon-gamma Independent CD8+ T cell-mediated protective anti-malaria immunity induced by recombinant adenovirus. Parasite Immunol. 22: 157-160.
  • Gonzalez-Aseguinolaza G, de Oliveira C, Koezuka Y, Nussenzweig RS, Van Kaer L, Bendelac A, Tsuji M. 1999. Protective role of NKT cells against liver stages of malaria infection in mice. Am. J. Trop. Med. Hyg. 61: 341
  • Fernandez JA, Zavala F, Tsuji M. 1999. Phenotypic and functional characterization of CD8+ T cell clones specific for a mouse cytomegalovirus epitope. Virology 155: 40-49.
  • Rodrigues EG, Zavala F, Nussenzweig RS, Wilson JM, Tsuji M. 1998. Efficient induction of protective anti-malaria immunity by recombinant adenovirus. Vaccine 16: 1812-17.
  • Rodrigues EG, Zavala F, Eichinger D, Wilson JM, Tsuji M. 1997. Single immunizing dose of recombinant adenovirus efficiently induces CD8+ T cell-mediated protective immunity against malaria. J. Immunol. 158: 1268-74.